{Reference Type}: Journal Article
{Title}: Determination of the Minimal Clinically Important Difference (MCID) for Ocular Subjective Responses.
{Author}: Navascues-Cornago M;Guthrie S;Morgan PB;Woods J;
{Journal}: Transl Vis Sci Technol
{Volume}: 13
{Issue}: 8
{Year}: 2024 Aug 1
{Factor}: 3.048
{DOI}: 10.1167/tvst.13.8.28
{Abstract}: <B>UNASSIGNED: </B>To determine the minimal clinically important difference (MCID) for contact lens (CL)-related subjective responses and explore whether MCID values differ between subjective responses and study designs.<BR><B>UNASSIGNED: </B>This was a retrospective analysis of data from seven one-week bilateral crossover studies and 14 one-day contralateral CL studies. For comfort, dryness, vision, or ease of insertion, participants rated on a 0-100 visual analogue scale (VAS) and indicated lens preference on a five-point Likert scale featuring strong, slight, and no preferences. For each criterion, four MCID estimates were calculated and averaged: mean VAS score difference for "slight preference," lower limit of 95% confidence interval VAS score difference for "slight preference," difference in mean VAS score difference between "slight" and "no preference" and 0.5 standard deviation of VAS scores.<BR><B>UNASSIGNED: </B>The four calculation methods generated a small range of MCID values. For bilateral studies, the averaged MCID was 7.2 (range 5.4-8.8) for comfort, 8.1 (5.2-10.6) for dryness, 7.1 (5.5-9.3) for vision and 7.6 (6.0-10.5) for ease of insertion. For contralateral studies, the averaged MCID was 6.9 (6.1-7.6) for comfort at insertion and 7.5 (6.8-8.2) for end-of-day comfort.<BR><B>UNASSIGNED: </B>This work demonstrated very similar MCID values across subjective responses and study designs, in a population of habitual soft CL wearers. In all cases, MCID values were on average seven units on a 0 to 100 VAS.<BR><B>UNASSIGNED: </B>This work provides MCID values which are important for interpreting ocular subjective responses and planning clinical studies.