{Reference Type}: Journal Article {Title}: Prolonged exposure to mixed reality alters task performance in the unmediated environment. {Author}: Wang XM;Southwick D;Robinson I;Nitsche M;Resch G;Mazalek A;Welsh TN; {Journal}: Sci Rep {Volume}: 14 {Issue}: 1 {Year}: 2024 08 15 {Factor}: 4.996 {DOI}: 10.1038/s41598-024-69116-w {Abstract}: The popularity of mixed reality (MR) technologies, including virtual (VR) and augmented (AR) reality, have advanced many training and skill development applications. If successful, these technologies could be valuable for high-impact professional training, like medical operations or sports, where the physical resources could be limited or inaccessible. Despite MR's potential, it is still unclear whether repeatedly performing a task in MR would affect performance in the same or related tasks in the physical environment. To investigate this issue, participants executed a series of visually-guided manual pointing movements in the physical world before and after spending one hour in VR or AR performing similar movements. Results showed that, due to the MR headsets' intrinsic perceptual geometry, movements executed in VR were shorter and movements executed in AR were longer than the veridical Euclidean distance. Crucially, the sensorimotor bias in MR conditions also manifested in the subsequent post-test pointing task; participants transferring from VR initially undershoot whereas those from AR overshoot the target in the physical environment. These findings call for careful consideration of MR-based training because the exposure to MR may perturb the sensorimotor processes in the physical environment and negatively impact performance accuracy and transfer of training from MR to UR.