{Reference Type}: Journal Article
{Title}: Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction.
{Author}: Jafarinia H;Khalilimeybodi A;Barrasa-Fano J;Fraley SI;Rangamani P;Carlier A;
{Journal}: NPJ Syst Biol Appl
{Volume}: 10
{Issue}: 1
{Year}: 2024 Aug 15
{Factor}: 4.671
{DOI}: 10.1038/s41540-024-00414-9
{Abstract}: YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with other pathways, and both mechanical and biochemical stimuli. Computational modeling serves as a powerful tool to unravel how these different factors can regulate YAP/TAZ, emphasizing biophysical modeling as an indispensable tool for deciphering mechanotransduction and its regulation of cell fate. We provide a critical review of the current state-of-the-art of computational models focused on YAP/TAZ signaling.