{Reference Type}: Journal Article
{Title}: Clinical Predictors of Nontuberculous Mycobacteria Lung Disease and Coisolates of Potential Pathogenic Microorganisms in Noncystic Fibrosis Bronchiectasis.
{Author}: Wang PH;Shu CC;Sheu CC;Chang CL;Hsieh MH;Hsu WH;Chen MT;Ou WF;Wei YF;Yang TM;Lan CC;Wang CY;Lin CB;Lin MS;Wang YT;Lin CH;Liu SF;Cheng MH;Chen YF;Cheng WC;Peng CK;Chan MC;Chen CY;Jao LY;Wang YH;Chen CJ;Chen SP;Tsai YH;Cheng SL;Lin HC;Chien JY;Wang HC;
{Journal}: Open Forum Infect Dis
{Volume}: 11
{Issue}: 8
{Year}: 2024 Aug
{Factor}: 4.423
{DOI}: 10.1093/ofid/ofae427
{Abstract}: <B>UNASSIGNED: </B>In bronchiectasis, nontuberculous mycobacteria (NTM) lung disease (NTM-LD) is a well-known coexisting infection. However, microorganism coisolates and clinical NTM-LD predictors are poorly studied.<BR><B>UNASSIGNED: </B>Patients with bronchiectasis diagnosed by means of computed tomography between January 2017 and June 2020 were screened, using the date of computed tomography as the index date. Those with a major bronchiectasis diagnosis in ≥2 follow-up visits after the index date were enrolled in the study, and NTM-LD occurrence and its association with pneumonia and hospitalization within 1 year were analyzed.<BR><B>UNASSIGNED: </B>Of the 2717 participants, 79 (2.9%) had NTM-LD diagnosed. The factors associated with NTM-LD included hemoptysis, postinfectious bronchiectasis, a tree-in-bud score ≥2, a modified Reiff score ≥4, and chronic obstructive pulmonary disease (adjusted odds ratios, 1.80, 2.36, 1.78, 2.95, and 0.51, respectively). Compared with patients in the non-NTM group, those with NTM-LD had higher rates of hospitalization (15.9% vs 32.9%; P < .001) and pneumonia (9.8% vs 20.3%; P = .003). Pseudomonas aeruginosa was the most common microorganism in those with NTM-LD and those in the non-NTM group (10.1% vs 7.8%; P = .40). However, compared with those in the non-NTM group, Acinetobacter baumannii and Escherichia coli were more prevalent in patients with NTM-LD (0.7% vs 3.8% [P = .03%] and 1.0% vs 3.8% [P = .05], respectively).<BR><B>UNASSIGNED: </B>Postinfectious bronchiectasis with hemoptysis, higher radiological involvement, and a tree-in-bud pattern were associated with NTM-LD risk. The rate of A baumannii and E coli coisolation was higher in bronchiectasis populations with NTM-LD.