{Reference Type}: Journal Article
{Title}: Prediction of neurologic outcome after out-of-hospital cardiac arrest: An interpretable approach with machine learning.
{Author}: Rawshani A;Hessulf F;Deminger J;Sultanian P;Gupta V;Lundgren P;Mohammed M;Abu Alchay M;Siöland T;Gryska E;Piasecki A;
{Journal}: Resuscitation
{Volume}: 202
{Issue}: 0
{Year}: 2024 Aug 12
{Factor}: 6.251
{DOI}: 10.1016/j.resuscitation.2024.110359
{Abstract}: Out-of-hospital cardiac arrest (OHCA) is a critical condition with low survival rates. In patients with a return of spontaneous circulation, brain injury is a leading cause of death. In this study, we propose an interpretable machine learning approach for predicting neurologic outcome after OHCA, using information available at the time of hospital admission.<BR><B>METHODS: </B>The study population were 55 615 OHCA cases registered in the Swedish Cardiopulmonary Resuscitation Registry between 2010 and 2020. The dataset was split to training and validation sets (for model development) and test set (for evaluation of the final model). We used an XGBoost algorithm with stratified, repeated 10-fold cross-validation along with Optuna framework for hyperparameters tuning. The final model was trained on 10 features selected based on the importance scores and evaluated on the test set in terms of discrimination, calibration and bias-variance tradeoff. We used SHapley Additive exPlanations to address the 'black-box' model and align with eXplainable artificial intelligence.<BR><B>RESULTS: </B>The final model achieved: area under the receiver operating characteristic value 0.964 (95% confidence interval (CI) [0.960-0.968]), sensitivity 0.606 (95% CI [0.573-0.634]), specificity 0.975 (95% CI [0.972-0.978]), positive predictive value (PPV) 0.664 (95% CI [0.625-0.696]), negative predictive value (NPV) 0.969 (95% CI [0.966-0.972]), macro F1 0.803 (95% CI [0.788-0.816]), and showed a very good calibration. SHAP features with the highest impact on the model's output were:'ROSC on arrival to hospital', 'Initial rhythm asystole' and 'Conscious on arrival to hospital'.<BR><B>CONCLUSIONS: </B>The XGBoost machine learning model with 10 features available at the time of hospital admission showed good performance for predicting neurologic outcome after OHCA, with no apparent signs of overfitting.