{Reference Type}: Journal Article {Title}: Risk of tuberculosis after initiation of antiretroviral therapy among persons with HIV in Europe. {Author}: Johansen IS;Roen A;Kraef C;Martín-Iguacel R;Nemeth J;Fenner L;Zangerle R;Llibre JM;Miller RF;Suarez I;de Wit S;Wit F;Mussini C;Saracino A;Canetti D;Volny-Anne A;Jaschinski N;Neesgaard B;Ryom L;Peters L;Garges HP;Rooney JF;Podlekareva D;Mocroft A;Kirk O; ; {Journal}: Int J Infect Dis {Volume}: 0 {Issue}: 0 {Year}: 2024 Aug 12 {Factor}: 12.074 {DOI}: 10.1016/j.ijid.2024.107199 {Abstract}: OBJECTIVE: Tuberculosis (TB) risk after initiation of antiretroviral treatment (ART) is not well described in a European setting, with an average TB incidence of 25/105 in the background population.
METHODS: We included all adult persons with HIV starting ART in the RESPOND cohort between 2012 and 2020. TB incidence rates (IR) were assessed for consecutive time intervals post-ART initiation. Risk factors for TB within 6 months from ART initiation were evaluated using Poisson regression models.
RESULTS: Among 8441 persons with HIV, who started ART, 66 developed TB during 34,239 person-years of follow-up [PYFU], corresponding to 1.87/1000 PYFU (95% confidence interval [CI]: 1.47-2.37). TB IR was highest in the first 3 months after ART initiation (14.41/1000 PY (95%CI 10.08-20.61]) and declined at 3-6, 6-12, and >12 months post-ART initiation (5.89 [95%CI 3.35-10.37], 2.54 [95%CI 1.36-4.73] and 0.51 [95%CI 0.30-0.86]), respectively. Independent risk factors for TB within the first 6 months after ART initiation included follow-up in Northern or Eastern Europe region, African origin, baseline CD4 count <200 cells/mm3, HIV RNA >100,000 copies/mL, injecting drug use and heterosexual transmission.
CONCLUSIONS: TB IR was highest in the first 3 months post-ART initiation and was associated with baseline risk factors, highlighting the importance of thorough TB risk assessment at ART initiation.