{Reference Type}: Journal Article
{Title}: CNGC15-DMI1 Gating in Nuclear Calcium Signaling: Opening New Questions and Closing Controversies.
{Author}: Jacott CN;Del Cerro P;
{Journal}: J Exp Bot
{Volume}: 0
{Issue}: 0
{Year}: 2024 Aug 14
{Factor}: 7.298
{DOI}: 10.1093/jxb/erae352
{Abstract}: Nuclear Ca²⁺ signaling is crucial for symbiotic interactions between legumes and beneficial microbes, such as rhizobia and arbuscular mycorrhizal fungi. Key to generating repetitive nuclear Ca²⁺ oscillations are the ion channels DMI1 and CNGC15. Despite over 20 years of research on symbiotic nuclear Ca²⁺ spiking, important questions remain, including the exact function of the DMI1 channel. This review highlights recent developments that have filled knowledge gaps regarding the regulation of CNGC15 and its interplay with DMI1. We also explore new insights into the evolutionary conservation of DMI1-induced symbiotic nuclear Ca²⁺ oscillations and the roles of CNGC15 and DMI1 beyond symbiosis, such as in nitrate signaling, and discuss new questions this raises. As we delve deeper into the regulatory mechanisms and evolutionary history of these ion channels, we move closer to fully understanding the roles of nuclear Ca²⁺ signaling in plant life.