{Reference Type}: Journal Article
{Title}: Rapidly progressive coronary atherosclerosis in a young male: a retrospective advanced CCT phenotype analysis.
{Author}: Lorenzatti D;Filtz A;Latib A;DeRose J;Dey D;Berman DS;Garcia MJ;Slipczuk L;
{Journal}: Int J Cardiovasc Imaging
{Volume}: 0
{Issue}: 0
{Year}: 2024 Aug 13
{Factor}: 2.316
{DOI}: 10.1007/s10554-024-03216-6
{Abstract}: We present a real-life case of a very young man with multiple risk factors who progressed rapidly from minimally obstructive non-calcified plaque on computed tomography angiography (CCTA) to severe three-vessel coronary disease presenting with STEMI. It questions the reliability of zero coronary calcium in high-risk subgroups like familial hypercholesterolemia, high Lp(a), and the young. While CCTA can accurately visualize non-calcified plaque, its interpretation requires expertise and clinical judgment should consider both imaging and clinical risk factors for management. Advanced plaque quantification, peri-coronary (PCAT), and epicardial (EAT) adipose tissue could help better-stratified patients but the evidence-based clinical application remains unknown.