{Reference Type}: Journal Article
{Title}: Correlation between endoscopic ultrasound features and exocrine pancreatic function in chronic pancreatitis.
{Author}: Stornello C;Deli C;Dell'Anna G;Lauri G;Ponz de Leon Pisani R;Tacelli M;Archibugi L;Vanella G;Apadula L;Rossi G;Zaccari P;Mariani A;Petrone MC;Cammà C;Arcidiacono PG;Capurso G;
{Journal}: Pancreatology
{Volume}: 24
{Issue}: 6
{Year}: 2024 Sep 8
{Factor}: 3.977
{DOI}: 10.1016/j.pan.2024.08.001
{Abstract}: <B>BACKGROUND: </B>Endoscopic ultrasound (EUS) is the most sensitive method for diagnosing chronic pancreatitis (CP) in its early stages, and Rosemont Classification (RC) is used for its evaluation. Data on the correlation between EUS features and pancreatic exocrine insufficiency (PEI) are limited. We investigated the correlation between the EUS findings and PEI.<BR><B>METHODS: </B>This was a retrospective, monocentric cohort study involving patients prospectively enrolled from 2018 to 2022, with definite or probable CP according to the M-ANNHEIM criteria. All the patients underwent EUS and exocrine function investigations within 12 months of diagnosis. PEI was diagnosed using fecal elastase (FE) or when overt steatorrhea was reversed by pancreatic enzyme replacement therapy. Logistic regression analyses, rank correlation, ROC curve, and area under the curve (AUROC) were performed to evaluate the association between EUS features and PEI, and the accuracy of RC in predicting PEI.<BR><B>RESULTS: </B>Among 128 patients examined (63.3 % male; mean age, 47 years), 69.5 % were diagnosed with PEI. In multivariate logistic regression among all the RC criteria, only lithiasis in the main pancreatic duct (MPD) was associated with increased risk of PEI (OR 2.92, 95 % CI 1.29-6.61; p = 0.01). Rank analysis showed a weak inverse correlation between RC and FE (Spearman's rho = -0.02; p = 0.03). The accuracy of RC was moderate (AUROC 0.62, p = 0.014).<BR><B>CONCLUSIONS: </B>Among RC EUS features, lithiasis in the MPD is helpful for predicting the risk of PEI, while other findings are of limited utility in evaluating exocrine function.