{Reference Type}: Journal Article {Title}: Assessing Cross-Border Telemedicine Data Exchange in the European Union: A Call to Action. {Author}: Lewerenz S;Martins D;Martins H; {Journal}: Telemed J E Health {Volume}: 0 {Issue}: 0 {Year}: 2024 Aug 13 {Factor}: 5.033 {DOI}: 10.1089/tmj.2024.0338 {Abstract}: Background: Telemedicine offers potential benefits for health care delivery. However, evidence of cross-border telemedicine data exchange within the European Union (EU) remains limited. The objective of this communication provides a brief outline of the regulatory framework, initiatives, and challenges associated with cross-border telemedicine data exchange in the EU, setting the stage for a comprehensive evidence assessment. Methods: We explore the current regulatory landscape (European Health Data Space), existing initiatives (the European Electronic Health Record Exchange Format), and interoperability challenges (e.g., legal, technical, semantic) facing EU cross-border telemedicine data exchange. Results: There is a need for thorough evidence assessment of cross-border telemedicine and related data movements. Conclusion: Understanding the current landscape of cross-border telemedicine is crucial. This article highlights the need for evidence assessment through a formal review to inform future research and policy initiatives in this domain.