{Reference Type}: Journal Article
{Title}: Clinico-mycological validation of dermatophytosis severity score and its correlation with patient-reported outcome measures.
{Author}: Bhat RM;Madhumita M;Jayaraman J;Antony B;Santosh G;Benny JV;Ancy A;
{Journal}: Mycoses
{Volume}: 67
{Issue}: 8
{Year}: 2024 Aug
{Factor}: 4.931
{DOI}: 10.1111/myc.13783
{Abstract}: <B>BACKGROUND: </B>Dermatophytosis impacts a significant portion of the global population. Recent shifts in the disease's presentation, severity and response to treatment, primarily due to emerging drug resistance, underscore the need for reliable assessment tools. The Dermatophytosis Severity Score (DSS) aims to standardise the evaluation of the disease's severity and monitor therapeutic responses.<BR><B>METHODS: </B>In a cross-sectional pilot study, 25 adults with clinically diagnosed dermatophytosis were evaluated using the DSS. The study also aimed to establish the correlation of DSS with different stages of treatment, dermatophyte species and patient-reported outcomes. Participants were recruited from a dermatology outpatient clinic, and the DSS was applied at baseline, Weeks 4 and 8. The validity and reliability of the DSS were assessed using statistical measures, including Cronbach's alpha and intraclass correlation coefficient.<BR><B>RESULTS: </B>The study comprised of a near-equal distribution of male (52%) and female (48%) patients, primarily within the age group of 20-39 years. A high recurrence rate of dermatophytosis (60%) was noted, and more than half of the patients (56%) had used topical steroids before presentation. The mean DSS significantly decreased from baseline to the final visit, mirroring the substantial reduction in the 5D itch scale and Dermatology Life Quality Index, with strong positive correlations observed between these measures.<BR><B>CONCLUSIONS: </B>The DSS demonstrated high inter-rater reliability and internal consistency, indicating its utility as a reliable clinical tool for assessing dermatophytosis severity. The strong correlation of DSS with itch intensity and quality of life validates its role in patient-centered care. Continued use and further validation of the DSS are recommended to enhance dermatophytosis management and treatment outcomes.