{Reference Type}: Journal Article
{Title}: Use of sedation-awakening electroencephalography in dogs with epilepsy.
{Author}: Wrzosek M;Banasik A;Czerwik A;Olszewska A;Płonek M;Stein V;
{Journal}: J Vet Intern Med
{Volume}: 0
{Issue}: 0
{Year}: 2024 Aug 12
{Factor}: 3.175
{DOI}: 10.1111/jvim.17153
{Abstract}: <B>BACKGROUND: </B>Electroencephalography (EEG) recording protocols have been standardized for humans. Although the utilization of techniques in veterinary medicine is increasing, a standard protocol has not yet been established.<BR><B>OBJECTIVE: </B>Assessment of a sedation-awakening EEG protocol in dogs.<BR><B>METHODS: </B>Electroencephalography examination was performed in a research colony of 6 nonepileptic dogs (control [C]) and 12 dogs with epilepsy admitted to the clinic because of the epileptic seizures.<BR><B>METHODS: </B>It was a prospective study with retrospective control. Dogs with epilepsy were divided into 2 equal groups, wherein EEG acquisition was performed using a "sedation" protocol (IE-S, n = 6) and a "sedation-awakening" protocol (IE-SA, n = 6). All animals were sedated using medetomidine. In IE-SA group, sedation was reversed 5 minutes after commencing the EEG recording by injecting atipamezole IM. Type of background activity (BGA) and presence of EEG-defined epileptiform discharges (EDs) were evaluated blindly. Statistical significance was set at P > 0.05.<BR><B>RESULTS: </B>Epileptiform discharges were found in 1 of 6 of the dogs in group C, 4 of 6 of the dogs in IE-S group, and 5 of 6 of the dogs in IE-SA group. A significantly greater number of EDs (spikes, P = .0109; polyspikes, P = .0109; sharp waves, P = .01) were detected in Phase 2 in animals subjected to the "sedation-awakening" protocol, whereas there was no statistically significant greater number of discharges in sedated animals.<BR><B>CONCLUSIONS: </B>A "sedation-awakening" EEG protocol could be of value for ambulatory use if repeated EEG recordings and monitoring of epilepsy in dogs is needed.