{Reference Type}: Journal Article {Title}: Unsupervised Domain Adaptation for Inter-Session Re-Calibration of Ultrasound-Based HMIs. {Author}: Lykourinas A;Rottenberg X;Catthoor F;Skodras A; {Journal}: Sensors (Basel) {Volume}: 24 {Issue}: 15 {Year}: 2024 Aug 4 {Factor}: 3.847 {DOI}: 10.3390/s24155043 {Abstract}: Human-Machine Interfaces (HMIs) have gained popularity as they allow for an effortless and natural interaction between the user and the machine by processing information gathered from a single or multiple sensing modalities and transcribing user intentions to the desired actions. Their operability depends on frequent periodic re-calibration using newly acquired data due to their adaptation needs in dynamic environments, where test-time data continuously change in unforeseen ways, a cause that significantly contributes to their abandonment and remains unexplored by the Ultrasound-based (US-based) HMI community. In this work, we conduct a thorough investigation of Unsupervised Domain Adaptation (UDA) algorithms for the re-calibration of US-based HMIs during within-day sessions, which utilize unlabeled data for re-calibration. Our experimentation led us to the proposal of a CNN-based architecture for simultaneous wrist rotation angle and finger gesture prediction that achieves comparable performance with the state-of-the-art while featuring 87.92% less trainable parameters. According to our findings, DANN (a Domain-Adversarial training algorithm), with proper initialization, offers an average 24.99% classification accuracy performance enhancement when compared to no re-calibration setting. However, our results suggest that in cases where the experimental setup and the UDA configuration may differ, observed enhancements would be rather small or even unnoticeable.