{Reference Type}: Journal Article
{Title}: Reducing Capillary Leak Syndrome Mortality in Extremely Premature Infants: A Pilot Investigation.
{Author}: Boly TJ;Lozano-Chinga MM;Reyes-Hernandez ME;Elgin TG;Ballas Z;Bermick JR;
{Journal}: Clin Pediatr (Phila)
{Volume}: 0
{Issue}: 0
{Year}: 2024 Aug 9
{Factor}: 1.701
{DOI}: 10.1177/00099228241272037
{Abstract}: Neonatal capillary leak syndrome (CLS) is a rare, but life-threatening condition following neonatal sepsis or inflammatory injury. The objective of this study was to describe a standardized treatment approach for CLS that improves mortality and neonatal outcomes. A retrospective cohort study of 10 infants born at 22 to 26 weeks of gestation who developed CLS following a significant inflammatory insult was performed. Time to diagnosis and treatment approaches over 2 epochs were recorded and described. In epoch 2, with increased clinical awareness of CLS and implementation of a standardized treatment approach, there was a non-statistically significant decrease in the time to treatment with a significant decrease in mortality. An early targeted treatment approach for neonatal CLS can decrease mortality rates in this highly morbid condition.