{Reference Type}: Journal Article
{Title}: Neck apposition is a key factor for aneurysm occlusion after Woven EndoBridge device embolization.
{Author}: Cortese J;Juhasz J;Rodriguez-Erazú F;Ghozy S;Bayraktar EA;Mihalea C;Zarrintan A;Ueki Y;Caroff J;Kallmes DF;Spelle L;Kadirvel R;
{Journal}: J Neurointerv Surg
{Volume}: 0
{Issue}: 0
{Year}: 2024 Aug 8
{Factor}: 8.572
{DOI}: 10.1136/jnis-2024-022155
{Abstract}: <B>BACKGROUND: </B>Sealing of the aneurysm neck with a Woven EndoBridge (WEB) device is recommended for disrupting the blood flow inside the aneurysm. This study investigates the relationship between WEB neck apposition and aneurysm occlusion rates.<BR><B>METHODS: </B>Aneurysms treated with a WEB from March 2017 to May 2022 at a single center were included. WEB neck apposition (poor/good) and WEB protrusion (yes/no) were evaluated on post-detachment high resolution cone beam CT images. Angiographic occlusion was assessed with the Bicêtre Occlusion Scale score (BOSS). Univariate and multivariable analysis tested the association between neck apposition and occlusion rates.<BR><B>RESULTS: </B>The study included 159 aneurysms in 141 patients (mean age 55.8±11.2 years; 64.2% women). Good neck apposition and protrusion were noted in 123 (77.4%) and 30 (18.9%) cases, respectively. Inter-rater agreements were good for neck apposition (κ=0.75) and protrusion (κ=0.78). Complete and adequate occlusion was achieved in 104 (65%) and 130 (82%) cases, respectively (median follow-up 18 months). Good neck apposition was a strong independent predictor for both adequate (adjusted OR (aOR)=5.9, 95% CI 2.4 to 14.9; P<0.001) and complete occlusion (aOR=7.1, 95% CI 3.0 to 18.1; P<0.001). Protrusion was more frequent in the adequate occlusion group versus the aneurysm recurrence group without reaching statistical significance (P=0.06), but was associated with more thromboembolic complications (9/30 (30%) vs 12/129 (9%); P<0.01). WEB shape modification was significantly greater in poor apposition cases (P=0.03).<BR><B>CONCLUSIONS: </B>Achieving good neck apposition of the WEB strongly predicts aneurysm occlusion during follow-up. WEB protrusion should be minimized due to the increase in thromboembolic risk with limited impact on aneurysm occlusion.