{Reference Type}: Journal Article
{Title}: A CARE-compliant article: A case report of retroperitoneal endometrial stromal sarcoma with multiple pulmonary metastases and literature review.
{Author}: Fang Y;Zhou X;Bai J;Lin Q;Zheng Y;Bo S;Sui L;Zhu T;Bai N;Sun L;
{Journal}: Medicine (Baltimore)
{Volume}: 103
{Issue}: 32
{Year}: 2024 Aug 9
{Factor}: 1.817
{DOI}: 10.1097/MD.0000000000039093
{Abstract}: <B>BACKGROUND: </B>Endometrial stromal sarcoma is an extremely rare mesenchymal neoplasm occurring in the extrauterine. Retroperitoneal endometrial stromal sarcoma with multiple pulmonary metastases, in particular, is extremely rare.<BR><B>METHODS: </B>Forty-seven-year-old woman (gravida 3, para 2), was referred to our institution with complaints of fever.<BR><B>METHODS: </B>Ultrasound and computed tomographic imaging of the abdomen identified the presence of masses in the pelvic region. Additionally, computed tomographic scans and X-ray evaluations of the thorax detected dispersed masses in both the lungs and pelvic area. Histopathological analysis of the pelvic region indicated the presence of low-grade endometrial stromal sarcoma. A computed tomography-guided pneumocentesis was conducted to further characterize the pulmonary lesions, confirming the diagnosis of low-grade endometrial stromal sarcoma.<BR><B>METHODS: </B>The patient underwent tumor resection, subsequent treatment with Medroxyprogesterone acetate for 6 months, received microwave ablation for multiple lung metastases, PARP1 inhibitor for 4 courses, and has been undergoing chemotherapy (epirubicin/ifosfamide) up to the present time.<BR><B>RESULTS: </B>Partial remission was obtained after the above treatment and this patient is now still alive maintaining for 3 years.<BR><B>CONCLUSIONS: </B>The identification and management of this disease remain a significant challenge due to its low prevalence. Further research involving a larger number of cases is necessary to ensure consistency in diagnosis and to establish effective treatment guidelines.