{Reference Type}: Journal Article
{Title}: Screening, epidemic trends and drug sensitivity analysis of nontuberculous mycobacteria in a local area of China.
{Author}: Lin WH;Yao C;Mei L;Wang DP;Bao XD;Liu SS;
{Journal}: Am J Transl Res
{Volume}: 16
{Issue}: 7
{Year}: 2024
{Factor}: 3.94
{DOI}: 10.62347/MAJY5046
{Abstract}: <B>OBJECTIVE: </B>To analyze the isolation rate, prevalence trends, species distribution, and drug sensitivity of non-tuberculous mycobacteria (NTM) in Anhui Province, providing a reference for diagnosis and treatment strategies.<BR><B>METHODS: </B>Specimens from suspected mycobacterial infection patients at Anhui Chest Hospital (including outpatients and inpatients) from January 2021 to December 2023 were cultured. Identified NTM strains were analyzed for species distribution and drug sensitivity.<BR><B>RESULTS: </B>Of 10,519 mycobacteria strains cultured, 1,589 were NTM (15.11%). The top four species were Mycobacterium intracellulare (75.36%), Mycobacterium abscessus (11.78%), Mycobacterium kansasii (7.09%), and Mycobacterium avium (2.85%). NTM strains showed high sensitivity to amikacin and clarithromycin (≥90%) and significant sensitivity to rifabutin, moxifloxacin, and rifampicin (89.03%-79.61%). They exhibited high resistance to imipenem/cilastatin, sulfamethoxazole, minocycline, and doxycycline (≥95%).<BR><B>CONCLUSIONS: </B>NTM isolation rates in Anhui have remained stable, with the predominant species being M. intracellulare, M. kansasii, M. abscessus, and M. avium. NTM strains are highly sensitive to amikacin, clarithromycin, rifabutin, moxifloxacin, and rifampicin. These findings can guide diagnosis, treatment strategies, and drug selection for NTM disease in Anhui Province.