{Reference Type}: Journal Article
{Title}: Language Markers of Dementia and Their Role in Early Diagnosis of Alzheimer's Disease: Exploring Grammatical and Syntactic Competence via Sentence Repetition.
{Author}: Kaltsa M;Tsolaki A;Lazarou I;Mittas I;Papageorgiou M;Papadopoulou D;Tsimpli IM;Tsolaki M;
{Journal}: J Alzheimers Dis Rep
{Volume}: 8
{Issue}: 1
{Year}: 2024
暂无{DOI}: 10.3233/ADR-230204
{Abstract}: <B>UNASSIGNED: </B>Earlier research focuses primarily on the cognitive changes due to Alzheimer's disease (AD); however, little is known with regard to changes in language competence across the lifespan.<BR><B>UNASSIGNED: </B>The present study aims to investigate the decline of language skills at the grammatical and syntactic levels due to changes in cognitive function.<BR><B>UNASSIGNED: </B>We administered the Litmus Sentence Repetition Task (SRT) to 150 native speakers of Greek who fall into five groups: 1) young healthy speakers, 2) cognitively intact elder healthy speakers, 3) speakers with subjective cognitive impairment (SCI), 4) speakers with mild cognitive impairment (MCI); and 5) speakers with AD dementia at the mild/moderate stages. All participants underwent a physical and neurological examination and cognitive screening with a standardized neuropsychological battery to assess cognitive status comprehensively and evaluate aspects like working memory, executive function, attention and memory to appropriately classify them.<BR><B>UNASSIGNED: </B>The data analysis revealed that the SRT had high discriminatory value in the development of AD; specifically, both accuracy and grammaticality indices were related to cognitive decline. Additionally, syntax significantly affected the performance of speakers with structures such as clitics being particularly challenging and in most structures the performance of speakers with MCI drops significantly compared to speakers with SCI.<BR><B>UNASSIGNED: </B>Linguistic indices revealed subtle early signs of cognitive decline that can be helpful in the early detection of AD, thus facilitating the clinical process offering support to language-based assessment tools such as sentence repetition, a non-invasive type of assessment to evaluate symptoms of AD.