{Reference Type}: Journal Article
{Title}: Anti-TNFα in inflammatory bowel disease: from originators to biosimilars.
{Author}: Zeng Z;Lin H;Jiang M;Yuan J;Li X;Jia Y;Yang L;Zhang H;
{Journal}: Front Pharmacol
{Volume}: 15
{Issue}: 0
{Year}: 2024
{Factor}: 5.988
{DOI}: 10.3389/fphar.2024.1424606
{Abstract}: The introduction of anti-tumor necrosis factor α (TNFα) biologics significantly innovated inflammatory bowel disease (IBD) treatment and increased medical costs. The recent expiration of patents of some anti-TNFα biologics (such as infliximab and adalimumab) facilitated the development of biosimilars. Comparable pharmacokinetic, efficacy, safety, and immunogenicity profiles between anti-TNFα originators and biosimilars were demonstrated in different studies. Anti-TNFα biosimilars hold promise for reducing the high cost of biologics and increasing patient access to biologics. In this review, we outline the current data on the use of anti-TNFα originators and biosimilars in patients with IBD, with a focus on the efficacy, safety, and immunogenicity profiles of infliximab and adalimumab biosimilars. The potential benefits, challenges, and future directions of anti-TNFα biosimilars are also discussed in the review.