{Reference Type}: Case Reports
{Title}: [Allogeneic haematopoietic stem cell transplantation induced remission of periarteritis nodosa associated with azacytidine-refractory myelodysplastic syndrome].
{Author}: Beurier P;Dallevet CA;Brissot E;Cholet C;Santin A;Lionnet F;Fain O;Mekinian A; ;
{Journal}: Rev Med Interne
{Volume}: 45
{Issue}: 8
{Year}: 2024 Aug 6
{Factor}: 0.885
{DOI}: 10.1016/j.revmed.2024.06.002
{Abstract}: <B>BACKGROUND: </B>Periarteritis nodosa (PAN) is a vasculitis affecting medium-vessel and may be associated with myelodysplastic syndrome. This association needs a simultaneous treatment of the vascular and the hematological disease. However limited data are available on the benefit of hematological treatment, and in particular allogeneic stem cell transplantation, in this situation.<BR><B>METHODS: </B>A 32-year-old patient with refractory periarteritis nodosa and simultaneous myelodysplastic syndrome, was treated with chemotherapy followed by hematopoietic stem cell allograft. The symptoms relating to PAN improved, allowing to decrease the dose of prednisone down to 5mg/d. However, a hematological relapse occurred two months later leading to the patient's death.<BR><B>CONCLUSIONS: </B>Hematopoietic stem cell allograft may represent a therapeutic option in the management of severe or refractory autoimmune diseases when the hematological indication is retained.