{Reference Type}: Journal Article
{Title}: IgG4-related Disease Concomitant with Diffuse Large B-cell Lymphoma.
{Author}: Yanagisawa H;Mishima K;Yamanouchi Y;Ueda Y;Yamano T;Iwao-Kawanami H;Sakai T;Kawanami T;Yamada K;Kawano M;Mizuta S;Fukushima T;Masaki Y;
{Journal}: Intern Med
{Volume}: 0
{Issue}: 0
{Year}: 2024 Aug 8
{Factor}: 1.282
{DOI}: 10.2169/internalmedicine.4010-24
{Abstract}: A 77-year-old man presented with right inguinal lymphadenopathy and swollen parotid and submandibular glands bilaterally. Histopathology revealed germinal center B-cell type diffuse large B-cell lymphoma (DLBCL) in the inguinal lymph node. Lymphocyte and plasma cell infiltration in the submandibular gland with elevated serum IgG4 levels (13 g/L) prompted a diagnosis of IgG4-related disease (IgG4-RD). Systemic chemotherapy for DLBCL led to shrinkage of the lymph nodes and disappearance of the submandibular gland swelling, as confirmed by fluorodeoxyglucose-positron emission tomography/computed tomography. Although concomitant IgG4-RD and lymphoma have been reported, their simultaneous diagnosis is rare; therefore, a biopsy of all involved organs is crucial in cases with unusual organ involvement.