{Reference Type}: Journal Article
{Title}: Clinical efficacy of gamma-oryzanol combined with Femoston for perimenopausal syndrome.
{Author}: Kuang YY;Xiong MQ;Cai JX;
{Journal}: World J Clin Cases
{Volume}: 12
{Issue}: 22
{Year}: 2024 Aug 6
{Factor}: 1.534
{DOI}: 10.12998/wjcc.v12.i22.4992
{Abstract}: <B>BACKGROUND: </B>Perimenopausal syndrome (PMS) is a chronic disease associated with estrogen deficiency. Because of the unsatisfactory outcomes of current conventional treatments for this condition, its treatment must be continuously explored and optimized.<BR><B>OBJECTIVE: </B>To assess the clinical effectiveness of γ-oryzanol in combination with Femoston for PMS.<BR><B>METHODS: </B>A total of 119 patients with PMS were selected from June 2023 to December 2023, which included 59 and 60 patients in the control and observation group, respectively. The control and observation groups were treated with Femoston and γ-oryzanol + Femoston, respectively. Comparative analyses were performed in terms of clinical effectiveness, safety (dizziness and headache, nausea and vomiting, and breast tenderness), sex hormones [estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH)], lumbar spine (L1-4) and bilateral femoral bone mineral density (BMD), and sleep quality (sleeping time and frequency of awakenings from sleep).<BR><B>RESULTS: </B>Compared with the control group, the observation group had statistically higher total effective rates of treatment; lower overall incidence of adverse events; higher post-treatment E2 levels and L1-4 and bilateral femoral BMD; and lower LH and FSH levels, sleeping time, and frequency of awakenings from sleep after treatment.<BR><B>CONCLUSIONS: </B>Therefore, for the treatment of PMS, γ-oryzanol combined with Femoston is significantly better than Femoston alone in terms of clinical effectiveness, exhibiting more pronounced clinical advantages in improving safety, sex hormone levels, BMD, and sleep quality.