{Reference Type}: Journal Article
{Title}: Weaning Outcome is Associated with ELWI and Impaired Diastolic Function.
{Author}: Bagka D;Zakynthynos G;Tsolaki V;Papanikolaou J;Vazgiourakis V;Baka M;Pratsas K;Makris D;
{Journal}: J Crit Care Med (Targu Mures)
{Volume}: 10
{Issue}: 1
{Year}: 2024 Jan
暂无{DOI}: 10.2478/jccm-2024-0008
{Abstract}: <B>UNASSIGNED: </B>To evaluate hemodynamic profiles of critical care patients undergoing spontaneous t-piece trial (SBT) and present weaning failure.<BR><B>UNASSIGNED: </B>Prospective observational study conducted in ready-to-wean non-cardiac ICU patients. Clinical, echocardiographic and thermodilution-derived variables were recorded before and after a 2-hour SBT. Weaning from mechanical ventilation was defined as preservation of spontaneous breathing for 48 hours following successful SBT.<BR><B>UNASSIGNED: </B>Fourteen patients succeeded weaning, five manifested T-trial-failure and six late-failure. Weaning outcome was significantly associated with ELWI(Extravascular lung-water index), global-end-diastolic index and impaired diastolic function, as indicated by pre-T Doppler early wave velocities (E/Em); Fifty-six percent of participants presented ELWI≥7mL/kg when fulfilling predetermined criteria for weaning. ELWI, impaired pulmonary permeability and left ventricular diastolic dysfunction were independent determinants of ELWI.<BR><B>UNASSIGNED: </B>ELWI before SBT and impaired diastolic function (as indicated by pre-T E/Em) might be weaning outcome determinants and their assessment may allow better risk stratification in weaning decision making.