{Reference Type}: Journal Article
{Title}: Relationship between rs1410996 polymorphism of CFH gene and essential hypertension patients of Han from Yunnan Province.
{Author}: Zhu C;Guo L;Yuan Y;Guo H;
{Journal}: Mol Biol Rep
{Volume}: 51
{Issue}: 1
{Year}: 2024 Aug 6
{Factor}: 2.742
{DOI}: 10.1007/s11033-024-09819-5
{Abstract}: <B>OBJECTIVE: </B>To explore the relationship between rs1410996 polymorphism of CFH gene and essential hypertension (EH) in the Yunnan Han population.<BR><B>METHODS: </B>rs1410996 of CFH gene was genotyped based on the collected clinical phenotypes of the EH patients (n = 520) and healthy people (n = 494).<BR><B>RESULTS: </B>On the genotype model and dominance model, there was no relationship between rs1410996 of CFH gene and EH after adjustment (P > 0.05). On the dominance model of male EH patients, the pulse pressure (PP) level of CC genotype carriers was higher than that of (CT + TT) genotype carriers after adjustment (P < 0.05).<BR><B>CONCLUSIONS: </B>rs1410996 of CFH gene has no correlation with the genetic susceptibility to EH in the Yunnan Han population, but it is related to the PP level in male patients.