{Reference Type}: Journal Article
{Title}: Cobalt-Catalyzed Intramolecular Markovnikov Hydrocarbonylation of Unactivated Alkenes via Hydrogen Atom Transfer.
{Author}: Jiang D;Li X;Xiao M;Cheng LJ;
{Journal}: Angew Chem Int Ed Engl
{Volume}: 0
{Issue}: 0
{Year}: 2024 Aug 5
{Factor}: 16.823
{DOI}: 10.1002/anie.202412828
{Abstract}: A cobalt-catalyzed intramolecular Markovnikov hydroalkoxycarbonylation and hydroaminocarbonylation of unactivated alkenes has been developed, enabling highly chemo- and regioselective synthesis of α-alkylated γ-lactones and α-alkylated γ-lactams in good yields. The mild reaction conditions allow use of mono-, di- and trisubstituted alkenes bearing a variety of functional groups. Preliminary mechanistic studies suggest the reaction proceeds through a CO-mediated hydrogen atom transfer (HAT) and radical-polar crossover (RPC) process, in which a cationic acylcobalt(IV) complex is proposed as the key intermediate.