{Reference Type}: Journal Article
{Title}: "Long-term safety and efficacy of injection mitomycin C(MMC) versus sponge application in trabeculectomies".
{Author}: Maheshwari D;Pillai MR;Hm P;Kader MA;Rengappa R;Pawar N;
{Journal}: Eur J Ophthalmol
{Volume}: 0
{Issue}: 0
{Year}: 2024 Aug 2
{Factor}: 1.922
{DOI}: 10.1177/11206721241266981
{Abstract}: <B>OBJECTIVE: </B>To compare the long-term safety and efficacy of subconjunctival injection mitomycin C(MMC) with conventional sponge applied MMC during trabeculectomy.<BR><B>METHODS: </B>Retrospective analysis of 98 eyes of 90 patients who underwent trabeculectomy with Mitomycin C were divided into two groups, group 1- sponge (n = 52) and group 2- Injection(n = 46). Follow-up data were collected on day one, day 15, one month, three months, six months, one year, two years and three years. Data from baseline and follow-up visits were analyzed and compared to study the significant difference in intraocular pressure (IOP), number of antiglaucoma medications (AGM) and best corrected visual acuity (BCVA) . P-value of <0.05 was considered statistically significant.<BR><B>RESULTS: </B>Mean preop IOP was 34.61 ± 13.3 mmHg in group one and 33.07 ± 9.6 mmHg in group two, which reduced to 11.43 ± 3.2 and 11.59 ± 3.2 mmHg at three years (p < 0.001 in both groups) with no significant difference between the groups. Mean number of preoperative AGM was 2.28 ± 0.8 and 2.42 ± 0.7 in group one and two respectively which reduced to 1.19 ± 1.1(p = 0.405) and 0.88 ± 0.9(p = 0.001) at three years. Complete and overall success rates (complete + qualified) were 59.3% and 78.9% in group one and 60.9% and 80.4% in group two at three years. No statistically significant difference was found in complication rates, post-operative interventions, and final visual outcome in both groups.<BR><B>CONCLUSIONS: </B>Subconjunctival Injection MMC was a safe and effective alternative to sponge application with comparable long term surgical outcomes.