{Reference Type}: Case Reports {Title}: Successful Treatment of Refractory Cutaneous Protothecosis With MAT2203, an Oral Lipid Nanocrystal Formulation of Amphotericin B. {Author}: Pechacek J;Schmitt MM;Ferrè EMN;Webb T;Goldberg J;Pathan S;Banerjee C;Barber P;DiMaggio T;Quinn A;Matkovits T;Castelo-Soccio L;Nussenblatt V;Lionakis MS; {Journal}: Open Forum Infect Dis {Volume}: 11 {Issue}: 8 {Year}: 2024 Aug {Factor}: 4.423 {DOI}: 10.1093/ofid/ofae428 {Abstract}: Prototheca wickerhamii is a rare cause of cutaneous and systemic infection that requires long treatment courses with potentially toxic medications. We describe a patient with cutaneous protothecosis refractory to triazole monotherapy who experienced clinical and radiographic improvement with the novel oral lipid nanocrystal formulation of amphotericin B without experiencing toxicity.