{Reference Type}: Journal Article
{Title}: Short-term effects of antenatal betamethasone on fetal cardiovascular and circulation status: A quasi-experimental observational (before-after) study.
{Author}: Hantoushzadeh S;Amiri A;Shabani A;Soufi Enayati Y;Mostafaeipour N;Houra Mousavi Vahed S;Nezamnia M;Sheykhian T;
{Journal}: Int J Reprod Biomed
{Volume}: 22
{Issue}: 5
{Year}: 2024 May
暂无{DOI}: 10.18502/ijrm.v22i5.16436
{Abstract}: <B>UNASSIGNED: </B>The administration of antenatal corticosteroid is a standard treatment to reduce the rate of perinatal mortality and morbidity; however, there is limited evidence regarding the potential effects of betamethasone on the constriction of the ductus arteriosus (DA).<BR><B>UNASSIGNED: </B>This study aimed to investigate the short-term effects of antenatal betamethasone on fetal cardiovascular and circulation status.<BR><B>UNASSIGNED: </B>This quasi-experimental observational (before-after) study was conducted on 32 singleton fetuses. The participants were healthy pregnant women with a diagnosis of placenta accreta spectrum who were eligible for 2 doses of betamethasone and referred to prenatal care clinic, Vali-E-Asr hospital, Tehran, Iran from January 2021-May 2022. The results of fetal echocardiography and Doppler sonography were compared before and after the administration of antenatal corticosteroid therapy.<BR><B>UNASSIGNED: </B>Following betamethasone injection, significant increases were observed in peak systolic and diastolic velocity of the DA without constriction of the DA (p < 0.001, p = 0.002 respectively). However, no significant changes were observed in right ventricular function, tricuspid valve function, Doppler of ductus venous, and peak systolic velocity of the aortic isthmus (p > 0.05). Doppler examination of the uterine, umbilical, and middle cerebral arteries also showed no significant changes (p > 0.05).<BR><B>UNASSIGNED: </B>Considering the benefits of antenatal corticosteroid therapy, its administration seems reasonable in preterm births. The transient changes in ductal blood flow are not prohibitive.