{Reference Type}: Journal Article
{Title}: Effect of Trehalose Disaccharide on Activation of Microglia and Indices of Systemic Inflammation in an Experimental Model of Alzheimer's Disease.
{Author}: Zozulya SA;Akopyan AA;Tenditnik MV;Ovsyukova MV;Korolenko TA;Klyushnik TP;Tikhonova MA;Pupyshev AB;
{Journal}: Bull Exp Biol Med
{Volume}: 177
{Issue}: 2
{Year}: 2024 Jun 2
{Factor}: 0.737
{DOI}: 10.1007/s10517-024-06157-1
{Abstract}: In an experimental model of Alzheimer's disease in mice, oral administration of trehalose disaccharide reduces neuroinflammation assessed by the expression level of microglia activation marker Iba1 and affects the neutrophil degranulation activity. A potential anti-inflammatory effect of 4% trehalose solution associated with a decrease in the activity of leukocyte elastase in plasma was revealed.