{Reference Type}: Journal Article
{Title}: Clinical and laboratory characteristics and outcome predictors of cerebral venous sinus thrombosis in a referral neurology hospital in Bangladesh.
{Author}: Moniruzzaman M;Been Sayeed SKJ;Das SC;Mostafa MG;Rashid MB;Mahmud R;Akhter M;Mehzabin R;Hossain SMR;Rahman MM;
{Journal}: J Int Med Res
{Volume}: 52
{Issue}: 8
{Year}: 2024 Aug
{Factor}: 1.573
{DOI}: 10.1177/03000605241266550
{Abstract}: <B>OBJECTIVE: </B>We aimed to describe clinical and laboratory characteristics and determine the predictors of outcome in patients with cerebral venous sinus thrombosis.<BR><B>METHODS: </B>This prospective study was conducted over 2 years among hospitalized patients with cerebral venous sinus thrombosis. Patient outcome was assessed using the Modified Rankin Scale (mRS) score at 3 months. Outcome predictors were identified using logistic regression analysis.<BR><B>RESULTS: </B>Eighty-one patients were included in this study. The median mRS outcome at 3 months was 1 (interquartile range 1-3). Poor outcomes were observed in 27.2% of patients, and the mortality rate was 9.8%. Factors associated with poor outcomes were age >60 years (relative risk [RR] 5.1), hemiparesis (RR 5.4), altered level of consciousness (RR 7.1), and transverse sinus involvement (RR 1.1). In general, mRS scores were not associated with D-dimer levels (RR 2.4). However, older patients with elevated D-dimer levels showed a significant association with poor outcomes (1.6) according to mRS scores.<BR><B>CONCLUSIONS: </B>Older age, hemiparesis, and altered consciousness levels were independent predictors of poor outcomes in patients with cerebral venous sinus thrombosis. High D-dimer level showed no association with functional disability, except in older patients.