{Reference Type}: Case Reports
{Title}: Early detection of multiple endocrine neoplasia type 1: A case report.
{Author}: Yuan JH;Luo S;Zhang DG;Wang LS;
{Journal}: World J Gastroenterol
{Volume}: 30
{Issue}: 26
{Year}: 2024 Jul 14
{Factor}: 5.374
{DOI}: 10.3748/wjg.v30.i26.3247
{Abstract}: <B>BACKGROUND: </B>Multiple endocrine neoplasias (MENs) are a group of hereditary diseases involving multiple endocrine glands, and their prevalence is low. MEN type 1 (MEN1) has diverse clinical manifestations, mainly involving the parathyroid glands, gastrointestinal tract, pancreas and pituitary gland, making it easy to miss the clinical diagnosis.<BR><B>METHODS: </B>We present the case of a patient in whom MEN1 was detected early. A middle-aged male with recurrent abdominal pain and diarrhea was admitted to the hospital. Blood tests at admission revealed hypercalcemia and hypophosphatemia, and emission computed tomography of the parathyroid glands revealed a hyperfunctioning parathyroid lesion. Gastroscopy findings suggested a duodenal bulge and ulceration. Ultrasound endoscopy revealed a hypoechoic lesion in the duodenal bulb. Further blood tests revealed elevated levels of serum gastrin. Surgery was performed, and pathological analysis of the surgical specimens revealed a parathyroid adenoma after parathyroidectomy and a neuroendocrine tumor after duodenal bulbectomy. The time from onset to the definitive diagnosis of MEN1 was only approximately 1 year.<BR><B>CONCLUSIONS: </B>For patients who present with gastrointestinal symptoms accompanied by hypercalcemia and hypophosphatemia, clinicians need to be alert to the possibility of MEN1.