{Reference Type}: Journal Article
{Title}: Prior traumatic brain injury is a risk factor for in-hospital mortality in moderate to severe traumatic brain injury: a TRACK-TBI cohort study.
{Author}: Yue JK;Etemad LL;Elguindy MM;van Essen TA;Belton PJ;Nelson LD;McCrea MA;Vreeburg RJG;Gotthardt CJ;Tracey JX;Coskun BC;Krishnan N;Halabi C;Eagle SR;Korley FK;Robertson CS;Duhaime AC;Satris GG;Tarapore PE;Huang MC;Madhok DY;Giacino JT;Mukherjee P;Yuh EL;Valadka AB;Puccio AM;Okonkwo DO;Sun X;Jain S;Manley GT;DiGiorgio AM; ;Badjatia N;Barber J;Bodien YG;Fabian B;Ferguson AR;Foreman B;Gardner RC;Gopinath S;Grandhi R;Russell Huie J;Dirk Keene C;Lingsma HF;MacDonald CL;Markowitz AJ;Merchant R;Ngwenya LB;Rodgers RB;Schneider ALC;Schnyer DM;Taylor SR;Temkin NR;Torres-Espin A;Vassar MJ;Wang KKW;Wong JC;Zafonte RD;
{Journal}: Trauma Surg Acute Care Open
{Volume}: 9
{Issue}: 1
{Year}: 2024
暂无{DOI}: 10.1136/tsaco-2024-001501
{Abstract}: <B>UNASSIGNED: </B><BR><B>UNASSIGNED: </B>An estimated 14-23% of patients with traumatic brain injury (TBI) incur multiple lifetime TBIs. The relationship between prior TBI and outcomes in patients with moderate to severe TBI (msTBI) is not well delineated. We examined the associations between prior TBI, in-hospital mortality, and outcomes up to 12 months after injury in a prospective US msTBI cohort.<BR><B>UNASSIGNED: </B>Data from hospitalized subjects with Glasgow Coma Scale score of 3-12 were extracted from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (enrollment period: 2014-2019). Prior TBI with amnesia or alteration of consciousness was assessed using the Ohio State University TBI Identification Method. Competing risk regressions adjusting for age, sex, psychiatric history, cranial injury and extracranial injury severity examined the associations between prior TBI and in-hospital mortality, with hospital discharged alive as the competing risk. Adjusted HRs (aHR (95% CI)) were reported. Multivariable logistic regressions assessed the associations between prior TBI, mortality, and unfavorable outcome (Glasgow Outcome Scale-Extended score 1-3 (vs. 4-8)) at 3, 6, and 12 months after injury.<BR><B>UNASSIGNED: </B>Of 405 acute msTBI subjects, 21.5% had prior TBI, which was associated with male sex (87.4% vs. 77.0%, p=0.037) and psychiatric history (34.5% vs. 20.7%, p=0.010). In-hospital mortality was 10.1% (prior TBI: 17.2%, no prior TBI: 8.2%, p=0.025). Competing risk regressions indicated that prior TBI was associated with likelihood of in-hospital mortality (aHR=2.06 (1.01-4.22)), but not with hospital discharged alive. Prior TBI was not associated with mortality or unfavorable outcomes at 3, 6, and 12 months.<BR><B>UNASSIGNED: </B>After acute msTBI, prior TBI history is independently associated with in-hospital mortality but not with mortality or unfavorable outcomes within 12 months after injury. This selective association underscores the importance of collecting standardized prior TBI history data early after acute hospitalization to inform risk stratification. Prospective validation studies are needed.<BR><B>UNASSIGNED: </B>IV.<BR><B>UNASSIGNED: </B>NCT02119182.