{Reference Type}: Case Reports {Title}: Catastrophic Case of West Nile Virus Rhombencephalitis in AIDS. {Author}: Sharma R;Salimi E;D'Assumpcao C;Valdez M;Chaudhry A;Heidari A;Kuran R;Bhandohal J; {Journal}: J Investig Med High Impact Case Rep {Volume}: 12 {Issue}: 0 {Year}: 2024 Jan-Dec 暂无{DOI}: 10.1177/23247096241267132 {Abstract}: West Nile Virus (WNV) belongs to the Flaviviridae family of viruses. It was first isolated and identified in 1937. Patients typically present with flu-like symptoms or are asymptomatic; however, neuroinvasive West Nile can lead to significant neurological impairment. Herein presented is a catastrophic case of WNV rhombencephalitis in a male patient newly diagnosed with AIDS. This report sheds light on the potential for severe neurological complications in co-infected patients and emphasizes the importance of early recognition.