{Reference Type}: Journal Article
{Title}: Quality of life following pelvic exenteration in neoplasms.
{Author}: Zanatto RM;Mucci S;Pinheiro RN;de Oliveira JC;Nicolau UR;Domezi JP;Silva DLE;Pracucho EM;Zanatto DO;Saad SS;
{Journal}: J Surg Oncol
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 30
{Factor}: 2.885
{DOI}: 10.1002/jso.27760
{Abstract}: <B>BACKGROUND: </B>Pelvic exenteration (PE) is an extensive surgical treatment reserved for advanced or recurrent pelvic neoplasms, with potential impacts on patients' quality of life (QoL) poorly referenced in the literature.<BR><B>OBJECTIVE: </B>This study aimed to evaluate QoL outcomes among three types of PE.<BR><B>METHODS: </B>A cross-sectional study assessed 106 patients divided into anterior PE (APE), posterior PE (PPE), or total PE (TPE) groups. QoL was measured using e short form 36 version 2 (SF-36) and the European Organization for Research and Treatment of Cancer QoL Quality of Life Questionnaire Core 30 (QLQ-C30) QoL questionnaires. Descriptive and inferential analyses compared questionnaire scores.<BR><B>RESULTS: </B>The findings unveiled a balance among the three groups concerning demographic variables and comorbidities, with the exception of a male predominance in the APE and TPE cohorts. Notably, the APE group exhibited elevated scores in overall health (assessed via SF-36) and social functioning and diarrhea domains (assessed via QLQ-C30). Moreover, in terms of the fatigue and nausea/vomiting domains (assessed via QLQ-C30), the APE group demonstrated superior QoL compared to the PPE group. Conversely, the PPE group manifested a notably lower QoL in the constipation domain (assessed via QLQ-C30) compared to the other two groups. Additionally, disease recurrence was significantly associated with diminished QoL across multiple domains.<BR><B>CONCLUSIONS: </B>APE patients exhibited better QoL than PPE and TPE groups, with disease recurrence adversely affecting QoL.