{Reference Type}: Case Reports
{Title}: Janus kinase inhibitor tofacitinib successfully treated palmoplantar pustulosis after switching from secukinumab: A case report and review of the literature.
{Author}: Fan Y;Yin R;
{Journal}: Int Immunopharmacol
{Volume}: 139
{Issue}: 0
{Year}: 2024 Sep 30
{Factor}: 5.714
{DOI}: 10.1016/j.intimp.2024.112762
{Abstract}: Palmoplantar pustulosis (PPP) is a chronic inflammatory recurrent disease characterized by sterile pustules involving palms and/or feet. Presently, there are no standard recommended treatment regimens. Tofacitinib is an oral Janus kinase (JAK) inhibitor, mainly acts on JAK 1 and 3 and has been approved for the treatment of rheumatoid arthritis in adults. Herein, we present a case of a patient with PPP who did not respond to IL-17A inhibitor secukinumab but was successfully treated by the JAK inhibitor tofacitinib.