{Reference Type}: Journal Article
{Title}: Cooperative NHC and Photoredox Catalyzed Radical Aminoacylation of Alkenes to Tetrahydropyridazines.
{Author}: Liu WD;Gao J;Mo JN;Zhou Y;Zhao J;
{Journal}: Chemistry
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 27
{Factor}: 5.02
{DOI}: 10.1002/chem.202402288
{Abstract}: Tetrahydropyridazines constitute an important structural motif found in numerous natural products and pharmaceutical compounds. Herein, we report an aminoacylation reaction of alkenes that enables the synthesis of 1,4,5,6-tetrahydropyridazines through cooperative N-heterocyclic carbene (NHC) and photoredox catalysis. This approach involves the 6-endo-trig cyclization of N-centered hydrazonyl radicals, generated via single-electron oxidation of hydrazones, followed by a radical-radical coupling step. The mild process tolerates a wide range of common functional groups and affords a variety of tetrahydropyridazines in moderate to high yields. Preliminary investigations using chiral NHC catalysts demonstrate the potential of this protocol for asymmetric radical reactions.