{Reference Type}: Journal Article
{Title}: STEMI, Revascularization, and Peak Troponin by Adverse Pregnancy Outcomes in Women With Myocardial Infarction.
{Author}: Handmark M;Lin A;Edsfeldt A;Sarno G;Fraser A;Rich-Edwards JW;Gonҫalves I;Pihlsgård M;Timpka S;
{Journal}: JACC Adv
{Volume}: 3
{Issue}: 8
{Year}: 2024 Aug
暂无{DOI}: 10.1016/j.jacadv.2024.101088
{Abstract}: <B>UNASSIGNED: </B>Women with a history of adverse pregnancy outcomes have a higher risk of coronary heart disease. Emerging evidence suggests that women with a history of preeclampsia have a different pattern of overall coronary atherosclerosis and that they at the time of myocardial infarction (MI) more frequently present with ST-segment elevation MI (STEMI) compared to women with no such history.<BR><B>UNASSIGNED: </B>The purpose of this study was to determine whether among women with MI, those with a history of adverse pregnancy outcomes are more likely to present with STEMI or other clinical characteristics indicating a more severe myocardial injury.<BR><B>UNASSIGNED: </B>The study sample consisted of 8,320 women aged ≤65 years with first MI in Sweden 2007 to 2022. Regression models were used to estimate the association between adverse pregnancy outcomes (hypertensive disorders of pregnancy [non-preeclamptic hypertension and preeclampsia], small for gestational age [SGA] infant, and preterm delivery) and STEMI, invasive revascularization, and high troponin, while considering known predictors of coronary heart disease.<BR><B>UNASSIGNED: </B>In total, 3,128 (38%) of women suffered STEMI. The adjusted OR of presenting with STEMI were higher in women with a history of preterm preeclampsia (OR: 1.40; 95% CI: 1.05-1.88), or an SGA infant (OR: 1.30; 95% CI: 1.13-1.50) compared to women with no such history, as well as for in-hospital revascularization. Stratified by infarct type, troponin levels did not differ by adverse pregnancy outcome history.<BR><B>UNASSIGNED: </B>Among women with a first MI, a history of preterm preeclampsia or SGA infant were associated with STEMI and invasive revascularization.