{Reference Type}: Journal Article
{Title}: B-Cell Induction Therapies in Intestinal Transplantation.
{Author}: Garcia J;Vianna R;
{Journal}: Gastroenterol Clin North Am
{Volume}: 53
{Issue}: 3
{Year}: 2024 Sep
{Factor}: 3.867
{DOI}: 10.1016/j.gtc.2024.01.001
{Abstract}: Despite advancements in short-term outcomes since the inception of intestinal transplant, significant long-term graft failure persists. Early successes are attributed to the utilization of tacrolimus for maintenance therapy, coupled with T-cell modulating induction regimens, which effectively reduce the incidence of acute cellular rejection. However, the challenge of chronic allograft injury remains unresolved. There is increasing evidence indicating a correlation between donor-specific antibodies and the survival of visceral allografts. Strategies aimed at reducing the presence or load of these antibodies may potentially enhance long-term outcomes. Consequently, our focus is now turning toward B-cell induction therapies as a possible solution.