{Reference Type}: Journal Article
{Title}: Computational approaches for clinical, genomic and proteomic markers of response to glucagon-like peptide-1 therapy in type-2 diabetes mellitus: An exploratory analysis with machine learning algorithms.
{Author}: Villikudathil AT;Mc Guigan DH;English A;
{Journal}: Diabetes Metab Syndr
{Volume}: 18
{Issue}: 7
{Year}: 2024 Jul 23
暂无{DOI}: 10.1016/j.dsx.2024.103086
{Abstract}: <B>BACKGROUND: </B>In 2021, the International Diabetes Federation reported that 537 million people worldwide are living with diabetes. While glucagon-like peptide-1 agonists provide significant benefits in diabetes management, approximately 40 % of patients do not respond well to this therapy. This study aims to enhance treatment outcomes by using machine learning to predict individual response status to glucagon-like peptide-1 therapy.<BR><B>METHODS: </B>We analysed a type-2 diabetes mellitus dataset from the Diastrat cohort, recruited at the Northern Ireland Centre for Stratified Medicine. The dataset included individuals prescribed glucagon-like peptide-1 therapy, with response status determined by glycated haemoglobin levels of ≤53 mmol/mol. We identified genomic and proteomic markers and developed machine learning models to predict therapy response.<BR><B>RESULTS: </B>The study found 5 genomic variants and 45 proteomic markers that help differentiate glucagon-like peptide-1 therapy responders from non-responders, achieving 95 % prediction accuracy with a machine learning model.<BR><B>CONCLUSIONS: </B>This study demonstrates the potential of machine learning in predicting the response to glucagon-like peptide-1 therapy in individuals with type-2 diabetes mellitus. These findings suggest that integrating genomic and proteomic data can significantly enhance personalized treatment approaches, potentially improving outcomes for patients who might otherwise not respond well to glucagon-like peptide-1 therapy. Further research and validation in larger cohorts are necessary to confirm these results and translate them into clinical practice.