{Reference Type}: Journal Article
{Title}: Skin Ultrasound Assessment of Patients with Systemic Scleroderma-An Observational Study.
{Author}: Palici C;Ciurea PL;Bita CE;Barbulescu AL;Florescu A;Musetescu AE;Vreju F;Dinescu SC;
{Journal}: J Pers Med
{Volume}: 14
{Issue}: 7
{Year}: 2024 Jul 8
{Factor}: 3.508
{DOI}: 10.3390/jpm14070734
{Abstract}: This study aims to analyze the changes in dermal thickness in patients with systemic scleroderma (SSc) in comparison with normal skin and also compare clinical forms with diffuse and limited cutaneous involvement. The study group consisted of female patients diagnosed with SSc with a disease history not exceeding 5 years. The areas of interest for ultrasound examination included the proximal phalanx of the third finger, the second intermetacarpal space, and the extension surface of the lower third of the forearm. The study included 20 patients diagnosed with SSc and 14 controls. SSc patients were subdivided into two subgroups based on the clinical form. Compared to the control group, patients with SSc had higher mean measurements in all three skin areas, with statistically significant differences in the hand and forearm areas. Patients with diffuse SSc displayed, on average, higher skin thickness compared to limited SSc in all skin areas examined, with a statistically significant difference only in the forearm area. Based on disease manifestations, significant differences were observed only with regard to the presence of pulmonary hypertension in the diffuse SSc group. In conclusion, skin ultrasound is a useful and accessible imaging method for diagnosing and quantifying dermal fibrosis in systemic scleroderma.