{Reference Type}: Journal Article
{Title}: The Evolution of Genetic Variability at the LRRK2 Locus.
{Author}: Guenther DT;Follett J;Amouri R;Sassi SB;Hentati F;Farrer MJ;
{Journal}: Genes (Basel)
{Volume}: 15
{Issue}: 7
{Year}: 2024 Jul 3
{Factor}: 4.141
{DOI}: 10.3390/genes15070878
{Abstract}: Leucine-rich repeat kinase 2 (LRRK2) c.6055G>A (p.G2019S) is a frequent cause of Parkinson's disease (PD), accounting for >30% of Tunisian Arab-Berber patients. LRRK2 is widely expressed in the immune system and its kinase activity confers a survival advantage against infection in animal models. Here, we assess haplotype variability in cis and in trans of the LRRK2 c.6055G>A mutation, define the age of the pathogenic allele, explore its relationship to the age of disease onset (AOO), and provide evidence for its positive selection.