{Reference Type}: Journal Article
{Title}: Crosstalk between kidney and bone: insights from CKD-MBD.
{Author}: Suzuki K;Soeda K;Komaba H;
{Journal}: J Bone Miner Metab
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 26
{Factor}: 2.976
{DOI}: 10.1007/s00774-024-01528-0
{Abstract}: The kidneys play an important role in the regulation of phosphate and calcium balance and serum concentrations, coordinated by fibroblast growth factor 23 (FGF23), parathyroid hormone (PTH), and 1,25-dihydroxyvitamin D (1,25D). In patients with chronic kidney disease (CKD), this regulation is impaired, leading to CKD-mineral and bone disorder (CKD-MBD), characterized by decreased 1,25D, elevated FGF23, secondary hyperparathyroidism, hyperphosphatemia, bone abnormalities, and vascular and soft-tissue calcification. While bone abnormalities associated with CKD-MBD, known as renal osteodystrophy, have been recognized as the most typical interaction between the kidney and bone, a number of other kidney-bone interactions have been identified, for which our knowledge of the pathogenesis of CKD-MBD has played an important role. This article summarizes recent findings on CKD-MBD and explores the crosstalk between the kidney and bone from the perspective of CKD-MBD.