{Reference Type}: Journal Article
{Title}: Loss of ARID1A 'loops' in STING.
{Author}: Goswami S;Sharma P;
{Journal}: Trends Immunol
{Volume}: 45
{Issue}: 8
{Year}: 2024 Aug 25
{Factor}: 19.709
{DOI}: 10.1016/j.it.2024.07.001
{Abstract}: In a recent article, Maxwell et al. report that loss of tumor cell-specific AT-rich interaction domain 1A (ARID1A), a component of the chromatin remodeling SWI/SNF complex, triggers antitumor immunity via R-loop-mediated upregulation of the type-I interferon (IFN) pathway. These recent findings uncover a molecular mechanism underlying improved responses to immune checkpoint therapy (ICT) seen in patients harboring an ARID1A loss-of-function mutation.