{Reference Type}: Journal Article
{Title}: Effect of Ganoderma lucidum on Cisplatin-induced Nephrotoxicity and Gastrointestinal Toxicity.
{Author}: Ota N;Endo S;Tatsunami R;Yamaguchi A;Wakame K;Nakata A;Sato K;
{Journal}: Anticancer Res
{Volume}: 44
{Issue}: 8
{Year}: 2024 Aug
{Factor}: 2.435
{DOI}: 10.21873/anticanres.17183
{Abstract}: <B>OBJECTIVE: </B>Cancer remains a major global health challenge, with an estimated 10 million cancer-related deaths in 2020, hindering efforts to extend life expectancy. Cisplatin, an effective platinum-based chemotherapeutic agent used against various malignancies, has numerous side effects. Ganoderma lucidum is a traditional Chinese medicine with extensive historical use and proven biological activity. This study investigated the effects of G. lucidum on cisplatin-induced nephrotoxicity and gastrointestinal toxicity.<BR><B>METHODS: </B>RAW264.7 cells were treated with cisplatin, G. lucidum, or both. Cytotoxicity and antioxidant capacity were measured. Slc:ICR (ICR) mice were treated with cisplatin, G. lucidum, or both. The survival rate and physiological data were measured.<BR><B>RESULTS: </B>G. lucidum suppressed cisplatin-induced cytotoxicity and apoptosis in RAW264.7 cells. G. lucidum suppressed cisplatin-induced nephrotoxicity and gastrointestinal toxicity via its antioxidant effects in ICR mice.<BR><B>CONCLUSIONS: </B>The suppressive mechanism of G. lucidum may be mediated via its antioxidant effects. These findings indicate its potential to reduce the side effects of cisplatin.