{Reference Type}: Journal Article
{Title}: Two new types of structures from soft coral-associated epiphytic fungus Aspergillus versicolor CGF9-1-2.
{Author}: He YP;Zhang ZK;Li ZJ;Wu PP;Hu JS;Fan H;Zhang CX;
{Journal}: Fitoterapia
{Volume}: 177
{Issue}: 0
{Year}: 2024 Sep 23
{Factor}: 3.204
{DOI}: 10.1016/j.fitote.2024.106136
{Abstract}: Global Natural Products Social (GNPS) molecular networking platform was applied to discovery the undescribed compounds from the common marine fungi Aspergillus versicolor CGF9-1-2, ultimately resulting in isolation of four new polyketides, decumbenone E (1), decumbenone F (2), 2'-epi-8-O-methylnidurufin (6), (-)-phomoindene A (7), one new nucleoside, 3-methyl-9-(2-methylbutene)-xanthine (8), and five known analogues. Their structures were elucidated based on 1D/2D NMR spectroscopic and HRESIMS data analyses, meanwhile, the absolute configurations of new compounds were established based on the X-ray crystallographic experiments, as well as the electronic circular dichroism (ECD) analysis. All compounds were predicted pharmaceutical chemistry with ten commonly disease-related proteins by molecular docking. In addition, all compounds against TDP1 were performed in vitro, which was consistent with the docking result, and compound 6 shown a weak inhibitory activity.