{Reference Type}: Journal Article
{Title}: Clinical study of chemotherapy-related cognitive impairment in patients with non-Hodgkin lymphoma.
{Author}: Wang QL;Xu HY;Wang Y;Wang YL;Lin PN;Chen ZL;
{Journal}: World J Psychiatry
{Volume}: 14
{Issue}: 7
{Year}: 2024 Jul 19
{Factor}: 3.5
{DOI}: 10.5498/wjp.v14.i7.1062
{Abstract}: <B>BACKGROUND: </B>Chemotherapy for malignant tumors can cause brain changes and cognitive impairment, leading to chemotherapy-induced cognitive impairment (CICI). Current research on CICI has focused on breast cancer and Hodgkin's lymphoma. Whether patients with non-Hodgkin's lymphoma (NHL) undergoing chemotherapy have cognitive impairment has not been fully investigated.<BR><B>OBJECTIVE: </B>To investigate whether NHL patients undergoing chemotherapy had cognitive impairments.<BR><B>METHODS: </B>The study included 100 NHL patients who were required to complete a comprehensive psychological scale including the Brief Psychiatric Examination Scale (MMSE) at two time points: before chemotherapy and within 2 wk of two chemotherapy courses. A language proficiency test (VFT), Symbol Number Pattern Test (SDMT), Clock Drawing Test (CDT), Abbreviated Daily Cognition Scale (ECog-12), Prospective and Retrospective Memory Questionnaire, and Karnofsky Performance Status were used to assess cognitive changes before and after chemotherapy.<BR><B>RESULTS: </B>The VFT scores for before treatment (BT) and after treatment (AT) groups were 45.20 ± 15.62, and 42.30 ± 17.53, respectively (t -2.16, P < 0.05). The CDT scores were 8 (3.5-9.25) for BT and 7 (2.5-9) for AT groups (Z -2.1, P < 0.05). Retrospective memory scores were 13.5 (9-17) for BT and 15 (13-18) for AT (Z -3.7, P < 0.01). The prospective memory scores were 12.63 ± 3.61 for BT and 14.43 ± 4.32 for AT groups (t -4.97, P < 0.01). The ECog-12 scores were 1.71 (1.25-2.08) for BT and 1.79 (1.42-2.08) for AT groups (Z -2.84, P < 0.01). The SDMT and MMSE values did not show a significant difference between BT and AT groups.<BR><B>CONCLUSIONS: </B>Compared to the AT group, the BT group showed impaired language, memory, and subjective cognition, but objective cognition and execution were not significantly affected.