{Reference Type}: Journal Article
{Title}: Causal effect of the age at first birth with depression: a mendelian randomization study.
{Author}: Guo W;Guo Y;Song S;Huang X;Zhang Y;Zhang A;Meng F;Chang M;Wang Z;
{Journal}: BMC Med Genomics
{Volume}: 17
{Issue}: 1
{Year}: 2024 Jul 24
{Factor}: 3.622
{DOI}: 10.1186/s12920-024-01966-9
{Abstract}: <B>BACKGROUND: </B>This study aimed to explore the causal relationship between age at first birth (AFB) and depression.<BR><B>METHODS: </B>Using the univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) methods to examine the potential correlation between age at first birth (AFB) and major depressive disorder and postpartum depression. A public database was used to obtain the genome-wide association studies (GWAS) summary data. We put inverse-variance-weighted (IVW) as the primary method in Mendelian randomization (MR) analysis and used sensitivity analysis to confirm the robustness of our result.<BR><B>RESULTS: </B>We found a significant causal association between AFB and major depressive disorder by using the IVW algorithm (odd ratio [OR] 0.826; 95% confidence interval [CI] 0.793 - 0.861; P = 4.51 × 10- 20). MR-Egger, weighted median, simple mode and weighted mode method concluded the same result (P < 0.05). During the sensitivity analysis, the heterogeneity test (Q-value = 55.061, df = 48, P = 2.81 × 10- 01, I2 = 12.82%) and the leave-one-out plot analysis confirmed the stability of the results. The outcomes of the pleiotropy test (MR-Egger intercept = 8.932 × 10- 3. SE = 6.909 × 10- 3. P = 2.02 × 10- 01) and MR_PRESSO global test (P = 2.03 × 10- 01) indicated there is no pleiotropy.<BR><B>CONCLUSIONS: </B>There is solid evidence that a higher age at first birth is associated with a lower risk of major depressive disorder.