{Reference Type}: Journal Article
{Title}: Ganospirones A-G, seven undescribed spiro-meroterpenoids from Ganoderma lucidum and their biological activities.
{Author}: Li D;Li SH;Gao Q;Luo Q;Cheng YX;
{Journal}: Phytochemistry
{Volume}: 227
{Issue}: 0
{Year}: 2024 Nov 22
{Factor}: 4.004
{DOI}: 10.1016/j.phytochem.2024.114226
{Abstract}: Ganoderma lucidum, a medicinal mushroom with a long history in traditional Chinese medicine, is widely used for chronic diseases. Ganospirones A-G (1-7), seven pairs of undescribed spiro-meroterpenoids, were isolated from the fruiting bodies of G. lucidum. Their structures including absolute configurations were characterized by using NMR spectroscopic data, ECD computational and X-ray diffraction methods. The anti-inflammatory and anti-renal fibrosis activities of the meroterpenoids 1-7 were tested, and the results revealed that (-)-2 and (+)-2 could inhibit iNOS expression in lipopolysaccharide-induced RAW264.7 cells at 20 μM.