{Reference Type}: Journal Article
{Title}: Nickel atom-clusters nanozyme for boosting ferroptosis tumor therapy.
{Author}: Liu H;Yu B;Zhou C;Deng Z;Wang H;Zhang X;Wang K;
{Journal}: Mater Today Bio
{Volume}: 27
{Issue}: 0
{Year}: 2024 Aug
{Factor}: 10.761
{DOI}: 10.1016/j.mtbio.2024.101137
{Abstract}: The translation of Fe-based agents for ferroptosis tumor therapy is restricted by the unstable iron valence state, the harsh catalytic environment, and the complex tumor self-protection mechanism. Herein, we developed a stable nickel-based single-atom-metal-clusters (NSAMCs) biocatalyst for efficient tumor ferroptosis therapy. NSAMCs with a nanowire-like nanostructure and hydrophilic functional groups exhibit good water-solubility, colloidal stability, negligible systemic toxicity, and target specificity. In particular, NSAMCs possess excellent peroxidase-like and glutathione oxidase-like activities through the synergistic influence between metal clusters and single atoms. The dual-enzymatic performance enables NSAMCs to synergistically promote efficient ferroptosis of cancer cells through lipid peroxidization aggregation and glutathione peroxidase 4 inactivation. Importantly, NSAMCs highlight the boost of ferroptosis tumor therapy via the synergistic effect between single-atoms and metal clusters, providing a practical and feasible paradigm for further improving the efficiency of ferroptosis tumor treatment.