{Reference Type}: Journal Article
{Title}: Understanding interobserver variability of pathologists to improve oral epithelial dysplasia grading.
{Author}: Ng GTE;Phang SC;Yu KS;Tiwari L;Khurram SA;Sloan P;Kujan O;
{Journal}: Oral Dis
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 22
{Factor}: 4.068
{DOI}: 10.1111/odi.15078
{Abstract}: <B>OBJECTIVE: </B>This study aimed to understand reasons for interobserver variability in the grading of oral epithelial dysplasia (OED) through a survey of pathologists to provide insight for improvements in the reliability and reproducibility of OED diagnoses.<BR><B>METHODS: </B>The study design included quantitative and qualitative methodology. A pre-validated 31-item questionnaire was distributed to general, head and neck, and oral and maxillofacial histopathology specialists worldwide.<BR><B>RESULTS: </B>A total of 132 pathologists participated and completed the questionnaire. Over two-thirds used the three-tier grading system for OED, while about a third used both binary and three-tier systems. Regular reporters of OED preferred the three-tier system and grading architectural features. Continuing education significantly aided recognition of architectural and cytological changes. Irregular epithelial stratification and drop-shaped rete ridges had the lowest prognostic value and recognition scores, while loss of epithelial cell cohesion had the highest. Most participants used clinical information and often sought a second opinion when grading OED.<BR><B>CONCLUSIONS: </B>Our study has found that frequency of OED reporting and attendance of CME/CPD can play an important role in grading OED. Variations in the prognostic value of individual histological features and the use of clinical information may further contribute to interobserver variability.